Anti-cancer retinoid
Proposed retinoid-like small molecule has shown promise results as an anticancer drug due to its ability to achieve a high therapeutic index. It is toxic to numerous cancer cell lines derived from a variety of primary tumors, including ovarian cancer, non-small cell lung cancer, leukemia, breast cancer, and squamous cell carcinoma.
After treatment with drug, cancer cells arrest in the S phase of the cell cycle and then undergo apoptosis, characterized by loss of mitochondrial membrane potential, release of cytochrome C, and activation of the caspase cascade. However, developed retinoid-like molecule does not induce apoptosis in normal human cells. Primary keratinocytes and normal human lung epithelial cells, after treatment, arrest in the G1/S phase of the cell cycle, after which cell death does not follow.
After treatment with drug, cancer cells arrest in the S phase of the cell cycle and then undergo apoptosis, characterized by loss of mitochondrial membrane potential, release of cytochrome C, and activation of the caspase cascade. However, developed retinoid-like molecule does not induce apoptosis in normal human cells. Primary keratinocytes and normal human lung epithelial cells, after treatment, arrest in the G1/S phase of the cell cycle, after which cell death does not follow.
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